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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HUWE1
All Species:
18.18
Human Site:
S2595
Identified Species:
50
UniProt:
Q7Z6Z7
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z6Z7
NP_113584.3
4374
481891
S2595
D
I
L
Q
L
S
S
S
L
P
L
Q
S
R
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001088987
4374
481661
S2595
D
I
L
Q
L
S
S
S
L
P
L
Q
S
R
G
Dog
Lupus familis
XP_538052
4375
482124
S2595
D
I
L
Q
L
S
S
S
L
P
L
Q
S
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q7TMY8
4377
482644
S2595
D
I
L
Q
L
S
S
S
L
P
L
Q
S
R
G
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001923899
4360
479137
S2587
D
I
L
Q
L
S
S
S
L
P
L
Q
S
R
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573059
5146
556842
L3151
W
W
L
E
E
A
T
L
L
D
M
E
S
Q
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500284
4177
465393
E2500
E
D
E
E
E
E
A
E
D
D
D
Q
D
E
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GY23
3681
404981
E2047
S
T
E
T
E
A
D
E
L
N
Q
N
N
S
S
Baker's Yeast
Sacchar. cerevisiae
Q03280
3268
374166
N1634
D
W
L
S
E
P
A
N
S
S
D
L
P
E
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
98.7
N.A.
97.7
N.A.
N.A.
N.A.
N.A.
N.A.
81.6
N.A.
33.7
N.A.
26.2
N.A.
Protein Similarity:
100
N.A.
99.7
99.1
N.A.
98.6
N.A.
N.A.
N.A.
N.A.
N.A.
88.4
N.A.
48.4
N.A.
44.3
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
100
N.A.
20
N.A.
6.6
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
100
N.A.
60
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.1
38.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
23
23
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
67
12
0
0
0
0
12
0
12
23
23
0
12
0
12
% D
% Glu:
12
0
23
23
45
12
0
23
0
0
0
12
0
23
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
56
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
56
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
78
0
56
0
0
12
78
0
56
12
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
12
0
12
0
12
12
0
12
% N
% Pro:
0
0
0
0
0
12
0
0
0
56
0
0
12
0
0
% P
% Gln:
0
0
0
56
0
0
0
0
0
0
12
67
0
12
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
56
0
% R
% Ser:
12
0
0
12
0
56
56
56
12
12
0
0
67
12
12
% S
% Thr:
0
12
0
12
0
0
12
0
0
0
0
0
0
0
12
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
12
23
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _